
Intra-dialytic hypotension (IDH) is defined as a fall in systolic blood pressure by ?20 mmHg or in mean arterial pressure (MAP) by 10 mmHg correlated with symptoms, which include nausea, abdominal discomfort, yawning, sighing, vomiting, muscle cramps, restlessness, dizziness or fainting, and anxiety. It is the most common complications associated with hemodialysis treatment, which impairs the well-being of patient. Apart from that, it can aggravate cardiac arrhythmias and influence the coronary or result in cerebral ischemic diseases. In addition, the clinical IDH obstructs with an accurate dose delivery of dialysis therapeutics, as hypotension episodes lead to the compartment effect and cause suboptimal Kt/vUrea. Amongst the global population suffering from kidney failure, 76% of dialysis patients are reported to consume anti- hypertensive medications. Intra-dialytic hypotension is observed in 15% of the hemodialysis patients.