Angelman syndrome is a rare genetic disorder that primarily affects the nervous system. It is estimated that, Angelman syndrome disorder usually occurs in one in 12,000 to 20,000 people in the general population. Angelman syndrome is caused by a loss of function in the UBE3A gene on the maternal 15th chromosome. People suffering from Angelman syndrome frequently laugh and smile, and have excitable personalities. The symptoms of Angelman syndrome include seizures, lack of speech, and balance issues. Other symptoms are tongue thrusting, developmental delays, jerky movements, small head size with flatness in the back of the head, and others. Presently, therapies for Angelman syndrome are supportive and symptomatic. The diagnosis of Angelman syndrome is done through a genetic test, in which a small amount of blood is taken from the patient and sent to a lab for testing. Tests review DNA pattern, gene mutation, and missing chromosomes.