
Conjugated estrogen is an active pharmaceutical ingredient that contains a mixture of steroidal and non-steroidal components that are obtained from pregnant mares' urine. Conjugated estrogen is used as an external source and is prescribed as a replacement of female natural hormones. Estrogen has many well-known effects on the tissues of the body. It causes the growth of the inner lining of uterus, secretion of cervix, development & growth of female sexual organs and maintains the sexual characteristics of females, such as hair growth of underarm and pubic area and countering of body and bone. Menopause is diagnosed when a woman has not had menses for one year. Due to the low production of estrogen in the body, about 85% of women have symptoms such as hot flushes, bone loss, vaginal dryness and shrinkage of tissues. For these symptoms, menopause hormone treatment therapy is the most effective treatment.