
Drug-induced nephrotoxicity or drug-induced kidney disease (DIKD) is primarily recognized as a significant contributor to kidney disease including acute kidney injury (AKI) and chronic kidney disease (CKD). Drug-induced nephrotoxicity is often go unrecognized, particularly in the setting of short drug exposures, which leads challenges in assessing the incidence, severity and long-term consequences of drug-induced kidney disease. The mechanisms for drug-induced nephrotoxicity include changes in glomerular hemodynamics, tubular cell toxicity, inflammation, crystal nephropathy, rhabdomyolysis, and thrombotic microangiopathy.