
Osteoporosis is a bone disorder characterized by low mineral density and bone mass, affecting 70 % of the U.S. population. Osteoporosis is most common in women than in men. These affected population are at high risk of fragility fracture, which most commonly occurs in wrist, upper arm, knee, hip and spine. Prevalence of osteoporosis is high among people aged 60 years and above. Moreover, estrogen plays a vital role in regulating the bone growth process in women. The rate of bone loss in women increases after menopause, leading to the threat of developing osteoporosis. Annually, 8.9 million fractures are reported to occur from osteoporosis across the globe. Anti-osteoporotic therapy is a treatment intended to increase bone mineral density and control the loss of bone tissue. Anti-osteoporosis can decrease the risk of subsequent fractures by 40%. Most of anti-osteoporosis therapy drugs are derived from the bisphosphonate molecule. Various studies have reported that these drugs can indeed increase bone mineral density (BMD) and reduce the risk of vertebral, hip, and other non-vertebral fractures in women with osteoporosis.