KEY PLAYERS: Medtronic plc, NuVasive, Inc., Stryker Corporation, Zimmer Biomet Holdings, Orthofix International N.V., Anika Therapeutics, Inc., DePuy Synthes (Johnson & Johnson), Bioventus, Arthrex, Inc., SeaSpine Holdings Corporation, Sanofi-Aventis (Sanofi SA), DJO Global, Inc., Seikagaku Corporation, RTI Surgical, Inc., Heraeus Holding GmbH, Fidia Pharma USA Inc., TRB Chemedica International SA, Allosource?, Musculoskeletal Transplant Foundation, Inc., Ito Co., Ltd.