Corn silk is made from a stigma, the yellowish thread like strands raising out of the female flower of maize. It is a waste material collected from corn cultivation which is available in abundance. Corn silk or stigma maydis is an important herb which is traditionally being used by the Chinese, and Americans to treat various diseases such as cystitis, edema, kidney stones, prostate disorder, diuretic, urinary infections, bedwetting and obesity. Corn Silk is also being used as a traditional medicine in many regions across the globe such as U.S., Turkey and France. It possess potential anti-oxidant properties and healthcare applications such as promoting diuresis, anti-depressant, in hyperglycemia reduction and as anti-fatigue agent which have been claimed all over across the globe. Moreover, corn silk is used as an extract in various products, such as dietary supplements and teas. The potential use of Corn Silk extract is related to its properties and mechanism of action of its constituents such as terpenoids and flavonoids.