Orthobiologics are the biologically derived materials from the body to promote the repair and regeneration of musculoskeletal tissues. When they are used in higher concentrations than normally present in the body, they can potentially help speed up the healing process. The substances which are considered to be Orthobiologics are: growth factors, DBM, cell based matrices, machined bone, bone substitute and others. These are capable of bone formation and encourage healing of fractures, nonunion, and repairing defects of various traumatic and non-traumatic conditions of skeletal system.