AAV: has the capacity to produce high titer virus with broad spectrum of tropism in dividing and non-dividing cells and potential for long-term gene transfer with minimum immnunogenicity. AAV1: CNS, Eye, Heart, Lung, Skeletal muscle AAV2: CNS, Eye AAV5: CNS, Eye, Lung AAV6: Adipose, Heart, Liver, Lung, Skeletal muscle AAV8: Adipose, CNS, Eye, Liver, Skeletal muscle; AAV9: Adipose, CNS, Eye, Heart, Liver, Lung, Skeletal muscle