On Sci-Fi television, in real forensic crime laboratories, and in analytical laboratories around the world, the technique of Mass Spectrometry is the well-established gold standard for food safety testing, explosives and chemical threat forensics, biotechnology research, drugs-of-abuse testing and clinical diagnostics. This broad utility comes both from Mass Spec’s high selectivity (it is able to differentiate millions of different chemicals) and from its extreme sensitivity (it is able to measure quantities as low as 1 part in a billion or better). Unlike television, until now, complexity, large size, and high costs restricted these capabilities to highly skilled scientists in laboratory environments. Samples, if they could be collected and moved, had to be transported to the instruments.