Immunotherapy, also called biologic therapy, is a cancer treatment that enhances the body's natural defenses to fight off cancer cells. In this therapy, the substance made by body or in laboratory to improve, restore, or target immune system function is used. Moreover, some immunotherapies that reduce or suppress the immune response are known as suppression immunotherapies. Cell-based therapies such as dendritic cells, includingmacrophages, natural killer cells, lymphocytes, cytotoxic T lymphocytes (CTL) are used certain types of cancer. These cells effectively protect the body against cancer by aiming for abnormal antigens involved on the façade of the tumor cells. Furthermore, therapies such as cellular membrane from bacteria are used for medical purpose. Some of the others such as IL-7, IL-2, IL-12, synthetic cytosine phosphate-guanosine (CpG) oligodeoxynucleotides and glucans and a variety of chemokines are involved in preclinical and clinical studies.