Systemic Lupus Erythematosus (SLE) is a chronic, multisystem, inflammatory autoimmune disease which leads to weakening of the immune system. It results in systemic inflammation which affects multiple organs such as kidneys, the tissue lining the lungs (pleura), heart (pericardium), and brain. Acute Cutaneous Lupus, Chronic or Discoid Lupus, Lupus Panniculitis, Lupus Pernio, Subacute Cutaneous Lupus and Tumid Lupus are the most common form of Systemic Lupus Erythematosus.