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Nitric oxide management systems such as nitric oxide flow regulation system, nitric oxide therapy system, nitric oxide delivery system and others consist features that have the potential to provide benefit for the patients. Nitric oxide management systems are used for cardiopulmonary conditions characterized by pulmonary hypertension – whether the patients are in critical care hospital settings, chronic care facilities, or even in the home. Nitric oxide management systems are especially designed for neonates to adults with a range of cardiopulmonary conditions. Nitric oxide (NO) is a significant biologically active molecule; its part in controlling cell and organ functions, particularly the, cardiovascular, nervous, respiratory and immune system. In the respiratory system, it is in charge of keeping up pulmonary vascular integrity. It enhances the blood vessel oxygenation, which might be related to its activity on the distribution of blood flow in the lungs. Manufacturers are keenly indulged in technological advancement to provide better and efficient nitric oxide management system to overcome cardiopulmonary management complication during the treatment.