Finding relief from migraine and chronic headache pain is no simple task. Studies have shown what migraine sufferers have learned firsthand – that most so-called treatments are just ineffective. The same research points to only four over-the-counter supplements have been clinically proven to reduce and prevent chronic headaches and migraines: Magnesium, Vitamin B-2 (Riboflavin), Feverfew (Tanacetum parthenium), and Butterbur (Petasites hybridus).