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A wide range of diseases, such as different types of cancer and degenerative diseases can be treated by deregulation of components involved in Wnt/?-catenin signaling pathway. Also, researchers have demonstrated that moderate weakening of Wnt signaling can eliminate its carcinogenic potential. Based on the recent researches, Wnt Signaling Pathway inhibitors have also shown potential in cardiovascular disorders.

Mitochondria are the organelles found in cytoplasm of most eukaryotic cells. They are also known as power-house of the cell. Various mitochondrial-related diseases have been discovered, in which the pathogenesis is not understood well. Currently, there are no approved drugs for the treatment of diseases caused due to mtDNA mutation.

LGS is a rare and severe form of epilepsy that mostly affects individuals during infancy or early childhood. This syndrome has the tendency to develop between the age of one to eight years in children, and can be characterized by polymorphic seizures and neuropsychological decline. The cause of this syndrome can be symptomatic, which is secondary to an underlying brain disorder or it can be cryptogenic, which means the exact cause of the disease is unknown.

JAK comprises four receptors JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2) which help in cytokine mediated signaling through the JAK/STAT pathway. There are two nearly identical phosphate transferring domains present in JAKs. The first domain demonstrates kinase activity while the other regulates the activity of the first via negative inhibition. The mutations in the JAK/STAT pathway leads to different medical conditions.

Rhinovirus infections, caused by rhinoviruses, occurs in the upper or lower respiratory tracts. The occurrence frequency of the infection is a year-around, but most often in spring and fall seasons. The infections are mostly acknowledged as 'common cold', but the infection can also lead to lesser degree pneumonia, sore throats, sinus infections, ear infections, and bronchiolitis.

As per the current scenario, there is not specific procedure developed to diagnose RLS; however, the symptoms can be treated primarily by incorporating changes in lifestyle and behavior. It can also be treated by prescription medications for sleeping, narcotic pain, iron treatment, seizures, and Parkinson's disease. Also, a number of therapeutic drugs are currently available in the market such as Horizant and Requip by GlaxoSmithKline plc, Neupro by UCB Biopharma SPRL, and Mirapex by Boehringer Ingelheim International GmbH.