Welcome to Depoe Bay's premium cannabis dispensary, Mr. Nice Guy Marijuana Dispensary Depoe Bay is located at 104 US-101. Right off the Coast Highway! Two steps away from the beach, Mr. Nice Guy is the perfect pitstop on your coastal journey. This local weed dispensary offers a huge selection of cannabis flower, concentrates, edibles, prerolls, CBD products & more. The number 1 dispensary in Depoe Bay, Oregon!