Hypoxemia is a common complication of childhood infections, particularly pneumonia. Pneumonia effects developing countries excessively, and accounted for over 2 million deaths per year globally. Hypoxemia is a recognized risk factor for death, and associates with disease severity and is hard to detect until onset of cyanosis. Smart pulse oximeter has been developed using a commercial wireless pulse oximeter and custom software for laptop, smartphone or computer. User friendly software has signal processing algorithms for heart rate, respiratory rate, and oxygen saturation from the plethysmographic waveform. Training module and clinical rules are under development. Increasing prevalence of cardiovascular disorders such as congestive heart failure, high blood pressure, coronary artery disease, cardiac arrest, arrhythmia, stroke, congenital heart diseases, and peripheral artery disease is expected to fuel the growth of smart pulse oximeters market during the forecast period.