
Bone marrow is the flexible and spongy tissue present inside bones. Bone marrow transplantation is a procedure in which damaged bone marrow is replaced with healthy bone marrow stem cells. Stem cells are immature cells found in the bone marrow and produce blood cells such as red blood cells (RBCs), white blood cells (WBCs), and platelets. Damaged bone marrow causes diseases such as aplastic anemia, leukemia, multiple myeloma, immunodeficiency disorders, and lymphoma. Bone marrow transplantation plays a vital role in the treatment of blood cancers such as leukemia, myeloma, and lymphoma. The transplantation procedure requires chemotherapy, radiation, or both, before the transplantation. The procedure is completed through either of two methods: high-dose chemotherapy and radiation therapy, and low-dose chemotherapy and radiation therapy. High-dose chemotherapy and radiation therapy damages cancer cells and destroys infected stem cells in the bone marrow and allows the generation of new stem cells in the bone marrow. In the second method, patients receive a lower dose of chemotherapy and radiation before transplantation. This method usually is used for aged patients and those with other health problems. There are three types of bone marrow transplantation: autologous bone marrow transplant, allogeneic bone marrow transplant, and umbilical cord blood transplant. In an autologous bone marrow transplant, the patient receives his or her own stem cells. In an allogeneic bone marrow transplant, stem cells are donated by another person. In an umbilical cord blood transplant, stem cells are removed from a newborns umbilical cord right after birth, which are stored in liquid nitrogen for their future use in transplantations. Some of the major side effects of bone marrow transplantation are mucositis (mouth sores) and diarrhea, nausea and vomiting, loss of hair, infertility, organ toxicity, and secondary cancers.