Cancer is a disease caused due to abnormal growth of cells. It leads to uncontrolled multiplication of cells into other tissues. Cancer cells can spread to other parts of the body through lymph and blood system. There are various types of cancers such as breast cancer, prostate cancer, lung cancer, colon cancer, skin cancer and lymphoma. Globally, it is the leading cause of deaths. Breast cancer is the most common form of cancer in women. According to World Health Organization (WHO) in 2012, approximately 8.2 million people died due to cancer. Similarly, according to American Cancer Society more than one million people suffer with cancer every year. Most cases of cancer are diagnosed and detected after a tumor is visible or felt. Tissue diagnostic plays crucial role for diagnosis, monitoring and management of cancer disease. Tissue diagnostics is also used for the diagnosis of next generation sequencing, decoding cancer molecular profiles and circulating tumor cells. Tissue diagnosis is done by fine needle aspiration cytology, open biopsy and core biopsy. The degree to which cancer has invaded the healthy tissue, stage and type of cancer can be determined with the help of biopsy. It helps to analyze the biopsy at molecular level to determine the course of treatment. Tissue diagnostics is used by pharmaceutical companies, contract research organizations, research laboratories and hospitals for the diagnosis of cancer. Some of the major tissue diagnostic tests are immunohistocheistry (IHC), hexatoxylin & eosin (H&E) and in situ hybridization (ISH).