Nonalcoholic steatohepatitis (NASH) is liver inflammation and damage caused by a buildup of fat in the liver. It is also known as silent liver disease. It is a type of nonalcoholic fatty liver disease (NAFLD), which mainly affects people with diabetes and obesity. Nonalcoholic Steatohepatitis (NASH) is defined by histological hallmarks of inflammation, hepatic steatosis, cell death, and fibrosis. A number of drugs used to treat medical situation have been NASH, such as amiodarone (Corderone, Pacerone), tamoxifen (Nolvadex), perhexiline maleate (Pexhid) and steroids (eg, prednisone). Medical studies have identified a strong connection of NASH with certain risk factors such as insulin resistance, oxidative stress and release of toxic inflammatory proteins.