Hyaluronic acid is also known as HA, hyaluronan or hyaluronate. It is a substance that is naturally present in the human body. Hyaluronic acid (HA) is an anionic, non-sulfated glycosaminoglycan circulated through the body in connective tissues, neural and epithelial tissues. It contributes significantly to cell proliferation and migration and is observed to be an integral component of the extracellular matrix. Orthopedic surgery, rheumatology, ophthalmology, otolaryngology and dermatology are the some application areas in which hyaluronic acid is use. Hyaluronic acid is also used as lip filler in plastic surgery. In addition, hyaluronic acid is used as lubricants and shock absorbers in various joint disorders, including osteoarthritis, dermal fillers, ophthalmic surgery and vesicoureteral reflux.