
Closure of the incision location after surgery or tissue / skin injury in emergency or trauma is a critical step in order to avoid blood loss and for tissue rejuvenation. This is achieved by many techniques like suturing, adhesive tapes, adhesive staples and tissue adhesives (chemicals). Tissue adhesives were introduced in 1980's for the closure of the incisions and injury or trauma sites. High viscosity tissue adhesives are widely used during surgeries also to stop the bleeding, which is not possible by techniques like suturing, electrocoagulation, etc. Among tissue adhesives available today, high viscosity tissue adhesives are used mainly for closure of wounds, injuries or traumas and post-operative incisions. High viscosity tissue adhesives have their own advantages such as ease of application, less time consumption, less risk of dehiscence, reduced infection, no scars, etc. The high viscosity tissue adhesives are different compounds / combinations of Cyanoacrylate. There are three major cyanoacrylate compounds available in market for high viscosity tissue adhesives viz. 2-Octyl Cyanoacrylate (2-OCA), n-2-Butyl Cyanoacrylate (n-2BCA) and 2-Ethyl Cyanoacrylate. All these variants differ in their characteristics like polymerization at specific temperature, strength, etc. 2-OCA and n-2BCA are commercially marketed by major suppliers, and mixture of the two is also marketed by several companies. Gelatin based gels of human fibrin were also in consideration for the surgical application in high viscosity tissue adhesives but are not available commercially.