Combination products was first defined in the U.S. Federal Food, Drug, and Cosmetic Act, twenty eight years ago. Combination product drug delivery includes combination of a biologic or drug with any drug delivery system. Combination product drug delivery is used for either augmenting the device's efficacy, for delivering a drug locally, or for providing safety with the use of drug coating. Combination product drug delivery systems are majorly used to treat conditions rather than to cure them. Combination product drug delivery systems offer improved performance, increase efficiency, and convenience. These combination product drug delivery devices enable the use of therapy candidates that are not capable of being used alone because of toxicities and systemic effects. Combination product technology also enables more effective and safer technologies due to precise and careful local administration, drug targeting, and individualized therapy. Combination product drug delivery technologies have paved the way for combination products that will help the population suffering from cardiovascular diseases, cancer, multiple sclerosis, spinal-cord injuries, cerebral palsy, anemia, rheumatoid arthritis, hepatitis, diabetes, other serious conditions and diseases.