Cancer is one of the leading causes of mortality for 1 in 7 individuals globally. It is globally acknowledged that early diagnosis and screening are of major importance for improving the likelihood of recovery. However, given the time-consuming, costly, and invasive nature of existing methods for cancer screening, patients often do not prefer these services. Researchers are focused on developing reliable, non-invasive, and fast diagnostic tools that can be directly used by the local physicians for point-of-care cancer screening. Incorporation of various biomarkers into point-of-care cancer screening devices is expected to potentially reduce the strain experienced by various healthcare systems and hospitals. Essentially, point-of-care cancer screening is capable of enhancing the well-being of patients and could further lead to a reduction in cancer-related deaths, globally. Point-of-care cancer screening tests are being miniaturized and simplified, for reducing the overall cost of equipment, materials, and personnel costs. The use of biosensor technologies and "lab-on-a-chip" has facilitated this change, making point-of-care cancer screening possible "on-site".