
Cancer molecular biomarker refers to a natural occurring molecule or gene in the living organism that is an indicator for the presence of cancer in the body. Biomarker is a measurable indicator of biological process, condition or a disease and can be found in blood, tissues or other body fluids. Cancer molecular biomarkers help to diagnose cancer, and check the patient's response for treatment and certain cancer therapies. On the basis of diagnostics, cancer molecular biomarkers can be segmented into immunoassays, immunohistochemical (IHC) tests, genetic and genomic markers, proteomics, flow cytometry, stem cell markers, monoclonal antibodies, pharmacogenomics, DNA microarrays and IVD multivariate index assays (IVDMIA). On the basis of discovery, cancer molecular biomarkers can be segmented into genetic methods, protein methods and imaging. Genetic methods include DNA arrays, southern blot, polymerase chain reaction (PCR), fluorescent in situ hybridization (FISH) and reverse transcriptase polymerase chain reaction (RT-PCR). Protein methods include immunohistochemistry (IHC) and mass spectrometry (MS). Imaging methods include positron emission tomography (PET), computed tomography (CT), magnetic resonance spectroscopy (MRS), x-ray, ultrasound, magnetic resonance imaging (MRI) and biophotonics.