Biological sensor also called as biosensor device made up of a transducer and biological element, nucleic acid, and antibody or an enzyme. Its biological element acts as a sensor and electrical component is used to detect and transmit the signal. Glucose biosensors transform a biological response into electrical signal and aid in measuring a wide spectrum of analysts together with, bacteria, gases, organic compounds and others. Monitoring blood glucose has been recognized as a helpful tool in managing diabetes. Depending on application, biosensors are recognized as biochips, resonant mirrors, biocomputers, optrodes, glucometers, immunosensors, and chemical canaries.