
Drug test is referred as analysis of biological samples such as urine, blood plasma, breath, and sweat. Specimen validity test (SVT) is defined as analysis of specimen to evaluate consistency with normal human urine. It is performed on specimen to detect dilution, substitution, or adulteration. The Substance Abuse and Mental Health Services Administration (SAMHSA) has provided guidelines that laboratories must follow while performing specimen validity testing. According to the SAMHSA guidelines, specimen validity testing consists of measurement of physical characteristics, creatinine level, specific gravity, pH, oxidizing adulterants, and interfering substances. SVT is an integral part of every urine drug screening and used routinely in several applications such as drug screening, pain management studies, and abuse testing.